Side effects of colon cancer drug, CPT-11
A team of scientists from the Weizmann Institute of Science, in collaboration with scientists in search of St. Jude Childrens Hospital in Memphis, Tennessee, showed exactly why this is a new drug has shown effectiveness against cancer colon often has serious side effects. His hope is that these results will help design drugs to improve in order to reduce the incidence of these side effects.in the body to work. The active drug molecule is packaged in a molecule that helps maintain stability when the drug injected. Inside the body, a natural enzyme interacts with the prodrug, by cutting a portion of the molecule to release a potent anti-cancer treatment.
The treatment of Alzheimers disease may be involved. Studies at the Weizmann Institute scientists Prof. Joel Sussman
and Dr. Michal Harel of the Department of Structural Biology and Prof. Israel Silman of the Neurobiology Department of the enzyme acetylcholinesterase (AChE) and its mode of action for many years and we have decided, with Dr. Phil Potter his team of researchers at Saint-Jew to see how this comes into play while working in the treatment of cancer. Scientists from the AChE crystal impregnated with a solution of CPT-11, obtaining crystals of the complex of both.Powerful X-ray crystal proteins produced a three-dimensional image of the dual structure of the protein, which shows exactly how the prodrug and the enzyme interacts. Comparing the structure of the complex with CPT-11/AChE computer-generated models of the enzymes that convert the drug, they found that the problem is a
suitable room. In all enzymes, CPT-11 molecule must enter a narrow cavity or groove in the structure of the enzyme.Throat enzymes AChE, is for the active site, can not break captured. Instead, make the prodrug, the enzyme as a block of cork, is useless. Enzymes are like locks that are made by the same locksmith, but varies slightly with different keys to open. The cancer drug AChE fits like a key that says the
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